Table 2 (A) Clinicopathological variables and miR-126 in tumor and stroma as predictors of disease-specific survival for colon cancer patients (univariate analyses, log-rank test, n = 452), (B) dichotomized miR-126 in tumor and stroma and their distribution over and correlation with clinicopathological variables (chi-square and Fisher’s exact tests).
From: High expression of microRNA-126 relates to favorable prognosis for colon cancer patients
A | B | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
N (%) | 5 Year | Median | HR (95%CI) | miR126 in tumor | miR126 in stroma | ||||||
P | Low | High | Low | High | P | ||||||
Age | 0.013 | 0.358 | 0.130 | ||||||||
≤ 65 | 110 (24) | 88 | NA | 1.00 | 78 | 30 | 89 | 20 | |||
> 65 | 342 (76) | 76 | NA | 1.83 (1.21–2.77) | 222 | 110 | 252 | 89 | |||
Gender | 0.388 | 0.751 | 1.000 | ||||||||
Female | 243 (54) | 78 | NA | 1.00 | 165 | 74 | 184 | 59 | |||
Male | 209 (46) | 81 | NA | 0.85 (0.58–1.23) | 135 | 66 | 157 | 50 | |||
Weight_loss | 0.012 | 0.092 | 0.621 | ||||||||
< 10% | 248 (55) | 82 | NA | 1.00 | 157 | 83 | 192 | 55 | |||
≥ 10% | 94 (21) | 68 | NA | 1.74 (1.06–2.87) | 69 | 22 | 70 | 24 | |||
Missing | 110 (24) | ||||||||||
ECOG_status | 0.424 | 0.997 | 0.993 | ||||||||
0 | 237 (52) | 82 | NA | 1.00 | 157 | 75 | 178 | 57 | |||
1 | 149 (33) | 76 | NA | 1.31 (0.86–1.99) | 98 | 45 | 113 | 36 | |||
2 | 54 (12) | 74 | NA | 1.18 (0.62–2.28) | 36 | 17 | 40 | 14 | |||
3 | 8 (2) | 50 | 47 | 2.31 (0.31–16.98) | 6 | 2 | 6 | 2 | |||
Missing | 4 (1) | ||||||||||
Site | 0.951 | 0.824 | 0.700 | ||||||||
Sigmoid | 227 (50) | 79 | NA | 1.00 | 152 | 69 | 171 | 56 | |||
Transversum | 65 (14) | 78 | NA | 0.94 (0.52–1.68) | 45 | 19 | 47 | 18 | |||
Left | 21 (5) | 80 | NA | 1.15 (0.47–2.78) | 14 | 5 | 18 | 3 | |||
Right | 136 (30) | 79 | NA | 1.09 (0.71–1.67) | 87 | 46 | 102 | 32 | |||
Missing | 3 (1) | ||||||||||
pStage | < 0.001 | 0.388 | 0.027 | ||||||||
1 | 72 (16) | 94 | NA | 1.00 | 46 | 25 | 53 | 19 | |||
2 | 219 (48) | 89 | NA | 2.27 (1.35–3.81) | 142 | 72 | 156 | 63 | |||
3 | 161 (36) | 59 | NA | 8.04 (4.58–14.11) | 112 | 43 | 132 | 27 | |||
Differentiation | < 0.001 | 0.311 | 0.006 | ||||||||
Well | 36 (8) | 89 | NA | 1.00 | 19 | 16 | 27 | 9 | |||
Moderate | 329 (73) | 78 | NA | 1.47 (0.76–2.82) | 224 | 98 | 259 | 68 | |||
Poor | 75 (17) | 79 | NA | 1.45 (0.67–3.15) | 49 | 22 | 48 | 27 | |||
Undifferentiated | 4 (1) | 25 | 10 | 11.34 (0.45–283.15) | 3 | 1 | 1 | 3 | |||
Missing | 8 (2) | ||||||||||
Vasc+ | < 0.001 | 0.305 | 0.575 | ||||||||
No | 199 (44) | 83 | NA | 1.00 | 121 | 69 | 151 | 48 | |||
Yes | 19 (4) | 45 | 30 | 5.22 (1.66–16.37) | 14 | 4 | 15 | 3 | |||
Missing | 234 (52) | ||||||||||
Resection margins | 0.005 | 0.519 | 0.630 | ||||||||
0 mm | 31 (7) | 54 | 68 | 1.00 | 23 | 6 | 26 | 5 | |||
< 1 mm | 42 (9) | 70 | NA | 0.56 (0.2–1.54) | 31 | 11 | 31 | 11 | |||
1–2 mm | 35 (8) | 88 | NA | 0.3 (0.11–0.85) | 21 | 14 | 25 | 10 | |||
2–10 mm | 121 (27) | 85 | NA | 0.33 (0.14–0.77) | 81 | 35 | 94 | 26 | |||
10–50 mm | 155 (34) | 80 | NA | 0.4 (0.17–0.95) | 100 | 50 | 112 | 43 | |||
> 50 mm | 46 (10) | 80 | NA | 0.3 (0.11–0.81) | 29 | 17 | 36 | 9 | |||
Missing | 22 (5) | ||||||||||
miR126 in tumor | < 0.001 | ||||||||||
Low | 300 (66) | 75 | NA | 1.00 | |||||||
High | 140 (31) | 88 | NA | 0.43 (0.29–0.64) | |||||||
Missing | 12 (3) | ||||||||||
miR126 in stroma | 0.005 | ||||||||||
Low | 341 (75) | 76 | NA | 1.00 | |||||||
High | 109 (24) | 88 | NA | 0.46 (0.29–0.71) | |||||||
Missing | 2 (0) | ||||||||||
