Figure 4
From: Characterization of the upstream and intron promoters of the gene encoding TAR DNA-binding protein
TARDBP exon 1 is crucial for upstream promoter activity. (a) Schematic representation of P16 (− 721/+ 1094), P16 (Δexon 1) and P16 (Δintron 1). (b) Luciferase assay of P1 (upstream promoter), P2 (intron 1 promoter) and P16. n = 3 replicates; one-way ANOVA with post hoc Dunnett’s test relative to P1. (c) Luciferase assay of P16, P16 (Δexon 1) and P16 (Δintron 1). n = 3 replicates; one-way ANOVA with post hoc Dunnett’s test relative to P16. All error bars indicate the means ± SEMs. **P < 0.01, ****P < 0.0001.
