Figure 4 | Scientific Reports

Figure 4

From: Isolation and characterisation of lymphatic endothelial cells from lung tissues affected by lymphangioleiomyomatosis

Figure 4

cDNA microarray analysis of LAM-LECs and control LECs. (a) Tree-view analysis of the average-linkage hierarchically clustered gene expression data. Genes in which mRNA expression changes 2 or more-fold between LAM-LECs (T) and control LECs are shown. The top dendrogram represents the similarity between individual arrayed samples (vertical plane) based on the global gene expression profile. (b) GSEA of LAM-LECs (T) compared to control LECs using gene sets included in the LEC-specific gene signatures, GO terms “endothelial cell proliferation” and “endothelial cell migration”. A nominal p‐value (Nom p) < 0.01 and a false discovery rate (FDR) < 0.25 were considered as statistically significant. (c) The heat map shows genes comprising the leading edge of the GSEA plot. Red indicates high expression; blue indicates low expression. Note that FLT4 encoding VEGFR-3 is identified as one of highly expressed genes in LAM-LECs (T) (arrowheads).

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