Figure 3

Histological analysis of synovitis in BL/6^C57 and BL/6^NZB operated mice. Representative images of Hematoxylin Eosin (H&E) stained sections from synovium of BL/6^C57 mice after DMM surgery (A, n = 9); synovial lining cell layer (a, black arrow), stroma cell density (b, blue arrow) and inflammatory infiltrate (c, red arrow). Representative images of Hematoxylin Eosin (H&E) stained sections from synovium of BL/6^NZB (B, n = 10) mice after DMM surgery; synovial lining cell layer (d, black arrow), stroma cell density (e, blue arrow) and inflammatory infiltrate (f, red arrow). Quantification of synovial lining cell layer (C), stroma cell density (D) and inflammatory infiltrate (E) in BL/6^C57 and BL/6^NZB operated mice. Quantification of synovitis total score in DMM groups from BL/6^C57 and BL/6^NZB mice (F). Original magnification 20×. Scale bar, 250 μm. All data are shown as mean ± SEM; *p < 0.05 by non-parametric Mann–Whitney test. Comparisons with significant differences are indicated; all other comparisons were non-significant.