Table 5 The PK parameters of etanercept for six healthy volunteers after they receive one subcutaneous injection of 50 mg etanercept.

From: A novel method for the storage and transport of biological samples of therapeutic proteins prior to the detection of analytes using ELISA

Parametersa

Sample storage methods

New method

Conventional method

t1/2 (h)

145.32 ± 72.07

174.71 ± 109.33

Tmax (h)

56.00 ± 31.90

52.00 ± 34.50

Cmax (μg/mL)

421.93 ± 169.00

427.13 ± 175.35

AUClast (μg/mL*h)

133,534.31 ± 54,189.32

133,830.22 ± 55,361.61

AUCinf (μg/mL*h)

138,932.98 ± 57,074.57

141,268.57 ± 59,629.49

MRTinf (h)

296.59 ± 57.53

307.31 ± 92.10

Vz/F (L)

118.06 ± 137.51

108.66 ± 73.90

Cl/F (L/h)

0.56 ± 0.60

0.57 ± 0.64

  1. aEach parameter was performed with a variance test, and the P value was bigger than 0.05.
Back to article page