Table 4 Cox proportional hazard model for overall survival in 149 patients.
Variable | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | p value | HR | 95% CI | p value | |
Age (≥ 65 years old) | 4.756 | 2.104–10.751 | < 0.001 | 2.823 | 1.187–6.713 | 0.019 |
Gender (male) | 1.667 | 0.801–3.470 | 0.172 | |||
Smoking history | 2.646 | 1.273–5.501 | 0.009 | 1.719 | 0.745–3.965 | 0.204 |
Preoperative CEA level (> 6.0 ng/mL) | 1.632 | 0.661–4.029 | 0.288 | |||
Maximum tumor dimension (> 30 mm)* | 3.066 | 1.472–6.384 | 0.003 | 1.959 | 0.911–4.213 | 0.085 |
Radiologic appearance (solid)* | 4.129 | 1.566–10.888 | 0.004 | 0.724 | 0.226–2.325 | 0.588 |
Pleural invasion (PL1, PL2, PL3)* | 3.254 | 1.374–7.706 | 0.007 | 1.888 | 0.687–5.190 | 0.218 |
Histology differentiation (poor)* | 3.784 | 1.781–8.041 | 0.001 | 1.410 | 0.531–3.741 | 0.490 |
Angiolymphatic invasion* | 2.633 | 1.232–5.629 | 0.013 | 1.041 | 0.422–2.571 | 0.930 |
Subtyping predominate (high-grade)* | 7.329 | 3.426–15.676 | < 0.001 | 3.287 | 1.323–8.168 | 0.010 |
Tumor distribution (bilateral) | 0.766 | 0.311–1.885 | 0.562 | |||
Tumor located in the same lobe | 0.855 | 0.378–1.934 | 0.706 | |||
Adjuvant chemotherapy | 1.632 | 0.661–4.029 | 0.288 | |||
Second dominant subtyping (invasive type)** | 4.514 | 1.706–11.949 | 0.002 | 1.879 | 0.654–5.396 | 0.241 |
