Figure 4 | Scientific Reports

Figure 4

From: Expression of CCL2/CCR2 signaling proteins in breast carcinoma cells is associated with invasive progression

Figure 4

hDCIS.01 xenografts enriched for CCR2 expression show increased CCL2, phospho-SMAD3 and phospho-p42/44MAPK expression. hDCIS.01 xenografts were immunostained for expression of: (A) CCL2, (B) CCR2, (C) phospho-SMAD3 or (D) phospho-p42/44MAPK. Normal adjacent tissues were from parental lesions. Normal adjacent n = 12, parental n = 14, CCR2+ n = 12. Expression was quantified by Image J. Statistical analysis was performed using One Way ANOVA with Bonferroni post-hoc comparison. Whisker box plots are shown. Whiskers indicate min and max values. Box indicates upper and lower quartile range. Line indicates median. Statistical significance was determined by p < 0.05. Scale bar = 200 microns.

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