Figure 7

(A) ‘Immunoscore’ scheme classification. Using the median CD45RA⁺ or CD45RO⁺ cell density of all analyzed cervical lesions samples as cut-off value, samples were classified as high or low CD45RA⁺ and high or low CD45RO⁺ in IE and MS separately. Subsequently, samples were subdivided into five groups (0–IV) according to their CD45RA⁺ and CD45RO⁺ cell infiltration of IE and MS as described previously by Lechner et al.⁵¹. Gray colored dots represent scores for defined parameters in low (none or one higher parameter), het (two higher parameters), or high (three or four higher parameters) ‘immunoscores’. (B) Percentage of grouped patients according to lesion severity classified in the ‘immunoscore’ levels.