Table 2 Summary of rheumatologic and non-rheumatologic irAEs.

All irAEs

212

100

Rheumatologic irAEs

31

15

Inflammatory arthritis

11

5

111.5 (34–539)

Rheumatoid arthritis

4

2

9 (5–25)

Psoriatic arthritis

4

2

59 (26–242)

Polymyalgia rheumatic

3

1.4

246 (28–379)

Gout

3

1.4

68 (2–75)

Arthralgias

3

1.4

91 (28–379)

Mixed connective tissue disease

1

0.5

*

Spondylitis

1

0.5

*

Leukocytoclastic vasculitis

1

0.5

359

Non rheumatologic irAEs

181

85

Skin

13

6

Non specified facial rash

2

1

197.5 (197–198)

Urticaria

1

0.5

7

Pemphigoid bullous

3

1.4

449 (327–469)

Eczematous dermatitis

2

1

28 (9–126)

Lichen planus

2

1

247.5 (215–280)

Lichen sclerosus

1

0.5

531

Vitiligo

2

1

54

Gastrointestinal

58

27

Colitis

29

14

126 (4–619)

Diarrhea

5

2.3

18 (5–795)

Hepatitis

18

8.5

70 (4–545)

Cholestatic liver disease

1

0.5

*

Cholangitis

1

0.5

163

Pancreatitis

4

2

118 (73–163)

Endocrine

72

34

Hypothyroidism

43

20

85 (7–342)

Thyroiditis

4

2

79 (20–146)

Adrenal insufficiency

14

7

118.5 (21–342)

Type I Diabetes mellitus

2

1

173.5 (33–314)

Hypophysitis

8

4

117 (21–341)

Hypogonadism

1

0.5

341

Pulmonary

25

12

Pneumonitis

25

12

57 (7–350)

Kidney

5

2.4

Interstitial nephritis

5

2.4

161.5 (15–577)

Eye

2

1

Uveitis

2

1

67

ENT

1

0.5

Laryngitis

1

0.5

84

Nervous system

2

1

Neurotoxicity

1

0.5

5

Headache

1

0.5

*

Heart

1

0.5

Myocarditis

1

0.5

41

Hematology

1

0.5

65

Autoimmune hemolytic anemia

1

0.5

Other

1

0.5

Cytokine release syndrome

1

0.5

*