Table 2 Characteristics of patients and chemotherapy regimen with trastuzumab.

From: PTEN is a predictive biomarker of trastuzumab resistance and prognostic factor in HER2-overexpressing gastroesophageal adenocarcinoma

(A)

Variables

 

PTEN loss

PTEN positive

p valuea

n = 29

n = 116

n

n

Age, years

Mean (SD)

68.4 (10.8)

68.2 (8.9)

0.915

Sex

Male

21 (72%)

81 (70%)

1.000

Female

8 (28%)

35 (30%)

 

BMI

Mean (SD)

19.5 (3.2)

21 (3.5)

0.041

Charlson Comorbidity Index

0 or 1

23 (79%)

99 (85%)

0.407

2 ≤

6 (21%)

17 (15%)

 

ECOG-PS

0 or 1

22 (76%)

86 (74%)

1.000

2 or 3

7 (24%)

30 (26%)

 

Primary site

Stomach

27 (93%)

113 (97%)

0.261

GE junction

2 (7%)

3 (3%)

 

Lauren classification

Intestinal

15 (52%)

53 (46%)

0.692

Diffuse

8 (28%)

30 (26%)

 

Mixed

6 (21%)

33 (28%)

 

Macroscopic type

Type 4

1 (3%)

14 (12%)

0.305

Other

28 (97%)

102 (88%)

 

HER2 score

2+

4 (14%)

20 (17%)

0.785

3+

25 (86%)

96 (83%)

 

Liver metastasis

Yes

9 (31%)

49 (42%)

0.298

Lung metastasis

Yes

5 (17%)

21 (18%)

1.000

Para-aorta LN metastasis

Yes

10 (34%)

45 (39%)

0.831

Bone metastasis

Yes

0 (0%)

9 (8%)

0.203

peritoneal dissemination

Yes

14 (48%)

34 (29%)

0.076

Number of metastatic sites

0–1

18 (62%)

73 (63%)

1.000

2 ≤

11 (38%)

43 (37%)

 

Previous chemotherapy

Yes

8 (28%)

16 (14%)

0.094

Previous gastrectomy

Yes

19 (66%)

26 (22%)

< 0.001

(B)

 

Variable

PTEN loss

PTEN positive

p valuea

 

n = 29

n = 116

n

n

Regimen

 

Trastuzumab alone

2 (7%)

1 (1%)

0.102

 

5-FU or S-1 or Cape

22 (76%)

108 (93%)

0.013

 

CDDP or L-OHP

19 (66%)

103 (89%)

0.004

 

Othersb

6 (21%)

10 (9%)

0.092

 
  1. (A) Characteristics of patients divided according to the phosphatase and tensin homolog (PTEN) status. (B) Chemotherapy regimen with trastuzumab.
  2. PTEN phosphatase and tensin homolog, GE gastroesophageal, HER2 human epidermal growth Factor Type2, 5-FU fluorouracil, S-1 tegafur/gimeracil/oteracil, Cape capecitabine, CDDP cisplatin, L-OHP oxaliplatin.
  3. aFisher’s exact test and Student’s t test were used for categorical items and continuous variables, respectively.
  4. bOthers include docetaxel, paclitaxel, and irinotecan.
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