Figure 3 | Scientific Reports

Figure 3

From: A novel cystathionine γ-lyase inhibitor, I194496, inhibits the growth and metastasis of human TNBC via downregulating multiple signaling pathways

Figure 3

I194496 inhibits the growth and proliferation of TNBC cells. (A) MTS assay was used to detect the effect of I194496 on the viability of MDA-MB-231 cells. *P < 0.05 vs Control group. ▲P < 0.05 vs 20 μM I194496 group. ΔP < 0.05 vs 30 μM I194496 group. #P < 0.05 vs PAG group. (B) MTS assay was used to detect the effect of I194496 on the viability of MDA-MB-468 cells. *P < 0.05 vs Control group. ▲P < 0.05 vs 24 μM I194496 group. ΔP < 0.05 vs 28 μM I194496 group. #P < 0.05 vs PAG group. (C, D) Comparison of the inhibitory effect of I194496 in normal breast epithelial cells and breast cancer cells. (E, F) EdU assay was performed to detect the proliferation of MDA-MB-231 and MDA-MB-468 cells. The results showed that I194496 decreased the EdU+ cell number in a dose-dependent manner. EdU, 5-ethynyl-2′-deoxyuridine. Image magnification, × 200.

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