Figure 6 | Scientific Reports

Figure 6

From: A novel cystathionine γ-lyase inhibitor, I194496, inhibits the growth and metastasis of human TNBC via downregulating multiple signaling pathways

Figure 6

I194496 inhibits the Anxa2/STAT3 and VEGF/FAK/Paxillin signalling pathways in human TNBC cells. (A, B) The effect of I194496 on Anxa2/STAT3 pathway in MDA-MB-231 cells. *P < 0.05 vs 0 μM I194496 group. ▲P < 0.05 vs 20 μM I194496 group. ΔP < 0.05 vs 30 μM I194496 group. (C, D) The effect of I194496 on Anxa2/STAT3 pathway in MDA-MB-468 cells. *P < 0.05 vs 0 μM I194496 group. ▲P < 0.05 vs 24 μM I194496 group. ΔP < 0.05 vs 28 μM I194496 group. (E, F) The effect of I194496 on VEGF/FAK/Paxillin signaling pathway in MDA-MB-231 cells. *P < 0.05 vs 0 μM I194496 group. ▲P < 0.05 vs 20 μM I194496 group. ΔP < 0.05 vs 30 μM I194496 group. (G, H) The effect of I194496 on VEGF/FAK/Paxillin signaling pathway in MDA-MB-468 cells. *P < 0.05 vs 0 μM I194496 group. ▲P < 0.05 vs 24 μM I194496 group. ΔP < 0.05 vs 28 μM I194496 group.

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