Table 1 List of common upregulated genes in palatable food and cocaine addicted mice.

From: Transcriptional signatures in prefrontal cortex confer vulnerability versus resilience to food and cocaine addiction-like behavior

Shared genes

Palatable food study

Cocaine study

Non-addiction (mean reads)

Addicted (mean reads)

log 2 fold change

p-value

padj

Non-addiction (mean reads)

Addicted (mean reads)

log 2 fold change

p-value

padj

Ankub1

21.84

33.10

0.60

0.001248

0.058955

31.40

57.41

0.87

9.61E − 06

0.000583

Gpr101

33.73

51.43

0.61

7.37E − 05

0.005809

20.94

33.99

0.70

0.002161

0.056409

4932418E24Rik

56.85

87.98

0.63

6.01E − 07

8.31E − 05

14.34

45.18

1.66

1.23E − 12

3.01E − 10

Pde10a

2323.67

3646.99

0.65

3.85E − 18

3.46E − 15

1960.02

4117.73

1.07

1.64E − 25

1.39E − 22

Spint1

35.14

55.36

0.66

1.33E − 05

0.001369

46.50

73.16

0.65

0.00015

0.006242

Penk

783.63

1248.17

0.67

1.88E − 18

1.76E − 15

671.88

2303.16

1.78

4.68E − 62

1.59E − 58

Foxj1

73.18

118.38

0.69

4.57E − 09

1.17E − 06

107.67

276.29

1.36

6.92E − 26

6.12E − 23

Lrrc74b

14.43

23.37

0.70

0.002005

0.08535

23.77

48.96

1.04

4.72E − 07

4.17E − 05

Mapk15

17.45

28.55

0.71

0.000452

0.025996

45.56

79.84

0.81

6.89E − 07

5.81E − 05

Thbs4

94.63

155.02

0.71

9.42E − 11

3.51E − 08

188.21

477.06

1.34

1.32E − 30

1.34E − 27

Ttc21a

24.79

40.92

0.72

4.2E − 05

0.003615

29.07

75.10

1.37

1.11E − 13

3.17E − 11

Dmkn

18.43

30.60

0.73

0.000159

0.010971

11.35

34.70

1.61

1.76E − 10

3.15E − 08

Prkcd

205.46

341.54

0.73

2.1E − 15

1.68E − 12

236.57

626.57

1.41

5.53E − 36

5.92E − 33

Cdhr3

16.90

28.15

0.74

0.000412

0.02409

24.36

56.50

1.21

2.32E − 09

3.3E − 07

Rgs9

885.90

1478.58

0.74

1.26E − 21

1.81E − 18

1029.04

2103.36

1.03

1.23E − 23

8.63E − 21

Ppp1r1b

1067.42

1790.87

0.75

6.36E − 22

9.81E − 19

1417.70

2698.42

0.93

3.47E − 19

1.91E − 16

Serpina9

48.40

81.38

0.75

1.01E − 08

2.25E − 06

8.67

92.99

3.42

1.39E − 57

3.53E − 54

Magel2

19.46

33.00

0.76

8.95E − 05

0.0068

75.29

134.84

0.84

3.81E − 09

5.19E − 07

Spag16

20.57

35.56

0.79

2.28E − 05

0.002163

13.82

30.39

1.14

1.04E − 05

0.000618

Drd1

459.60

798.51

0.80

1.22E − 22

2.02E − 19

553.74

847.85

0.61

1.5E − 08

1.74E − 06

Top2a

38.44

67.88

0.82

1.12E − 08

2.44E − 06

57.25

162.06

1.50

4.47E − 25

3.63E − 22

Gpr88

687.07

1234.93

0.85

7.12E − 27

2.2E − 23

727.44

1946.91

1.42

8.86E − 41

1.5E − 37

Clic6

37.33

67.53

0.86

1.5E − 09

4.37E − 07

16.57

101.70

2.62

1.87E − 44

3.47E − 41

Lrp2

15.82

28.67

0.86

3.37E − 05

0.003035

6.65

30.57

2.20

3.34E − 14

1.08E − 11

Npffr1

12.30

22.48

0.87

0.000135

0.009712

8.56

23.89

1.48

3.21E − 07

3.04E − 05

Tmem212

9.08

17.53

0.95

0.000385

0.022814

16.63

56.32

1.76

6.11E − 16

2.44E − 13

Clspn

11.08

21.68

0.97

4.45E − 05

0.003739

12.07

33.78

1.48

7.35E − 09

9.58E − 07

Lrrc10b

142.24

282.65

0.99

3.03E − 25

6.54E − 22

62.90

389.65

2.63

1.97E − 88

4.02E − 84

Galr1

6.02

12.02

1.00

0.001666

0.074447

2.92

10.22

1.81

1E − 04

0.004421

Ak7

13.11

27.10

1.05

1.74E − 06

0.000222

30.52

93.19

1.61

7.26E − 20

4.22E − 17

Isl1

18.45

38.22

1.05

5.41E − 09

1.33E − 06

6.83

32.99

2.27

1.16E − 15

4.43E − 13

Myb

7.13

14.91

1.06

0.00027

0.017218

13.80

34.27

1.31

1.78E − 07

1.81E − 05

Ido1

7.40

15.65

1.08

9.76E − 05

0.007287

5.78

28.07

2.28

7.38E − 14

2.21E − 11

Tacr3

14.57

31.15

1.10

5E − 08

9.47E − 06

15.21

26.95

0.82

0.001561

0.044583

Syndig1l

113.16

243.70

1.11

1.6E − 28

5.77E − 25

102.68

447.41

2.12

2.1E − 64

8.54E − 61

Adora2a

168.79

369.92

1.13

7.78E − 35

5.6E − 31

74.89

381.74

2.35

9.45E − 73

9.61E − 69

Dlk1

23.52

52.47

1.16

4.78E − 12

2.29E − 09

172.22

258.57

0.59

6.7E − 07

5.68E − 05

Cd4

24.91

55.89

1.17

5.74E − 13

3.02E − 10

21.88

123.46

2.50

2.89E − 46

6.53E − 43

Prdm12

9.18

20.78

1.18

2.94E − 06

0.000349

5.05

54.69

3.44

1.17E − 39

1.59E − 36

Slc5a7

39.33

91.36

1.22

2.13E − 19

2.42E-16

36.94

84.27

1.19

8.29E − 12

1.87E − 09

Six3os1

12.25

29.58

1.27

1.76E − 09

5E − 07

3.27

31.91

3.29

1.64E − 23

1.11E − 20

Sh3rf2

34.41

84.86

1.30

6.75E − 21

8.09E − 18

7.07

101.83

3.85

1.91E − 69

1.3E − 65

Gpr6

45.40

111.95

1.30

1.03E − 24

2.02E − 21

17.90

101.01

2.50

2.21E − 40

3.46E − 37

Ccdc180

8.33

20.67

1.31

4.14E − 07

6.03E − 05

10.88

31.47

1.53

1.26E − 08

1.49E − 06

Ecel1

77.64

197.97

1.35

2.43E − 35

2.62E − 31

85.46

165.11

0.95

2.11E − 11

4.3E − 09

Six3

9.84

25.17

1.35

4.57E − 09

1.17E − 06

6.40

85.56

3.74

1.43E − 59

4.15E − 56

Glp1r

18.56

47.50

1.36

4.5E − 14

2.78E − 11

4.59

39.01

3.09

2.8E − 26

2.59E − 23

Ccdc153

12.15

31.77

1.39

1.19E − 10

4.2E − 08

21.63

88.32

2.03

7.75E − 27

7.5E − 24

Chat

17.07

45.10

1.40

1E − 14

7.22E − 12

4.27

31.27

2.87

7.11E − 20

4.22E − 17

Slc10a4

8.88

24.69

1.48

5.42E − 10

1.72E − 07

6.12

29.48

2.27

1.33E − 14

4.57E − 12

Spata18

3.75

10.57

1.50

4.45E − 05

0.003739

6.04

26.49

2.13

1.45E − 11

3.09E − 09

Drd2

56.60

160.87

1.51

3.58E − 38

7.74E − 34

59.07

305.98

2.37

7.48E − 68

3.8E − 64

Ankk1

5.69

16.99

1.58

5.24E − 08

9.72E − 06

2.12

15.32

2.85

4.03E − 11

8.05E − 09

Fam216b

4.64

14.62

1.66

2.15E − 07

3.36E − 05

14.79

53.67

1.86

3.06E − 17

1.48E − 14

Ntrk1

6.54

22.53

1.78

5.51E − 12

2.58E − 09

1.39

13.79

3.31

9.46E − 12

2.09E − 09

Gpx6

3.73

16.31

2.13

2.89E − 11

1.18E − 08

0.66

11.25

4.09

2.21E − 11

4.45E − 09