Table 5 Significant associations between maternal and perinatal factors and survival of pediatric astrocytoma, ependymoma, and medulloblastoma cases.

From: Maternal and perinatal factors are associated with risk of pediatric central nervous system tumors and poorer survival after diagnosis

Maternal and perinatal characteristics

Astrocytoma

Cases

Unadjusted model

Adjusted modela

HR

95% CI

P-valueb

HR

95% CI

P-valueb

Maternal race/ethnicity

Non-hispanic white

480 (49.5)

Reference

Reference

Non-hispanic black

101 (10.4)

1.68

1.11–2.56

0.015

1.66

1.08–2.56

0.020

Hispanic

357 (36.8)

1.27

0.94–1.72

0.121

1.30

0.95–1.79

0.105

Other

32 (3.3)

1.89

0.98–3.64

0.056

1.98

0.99–3.95

0.054

Missing

0 (0.0)

      
 

Ependymoma

Maternal nativity

U.S. born

99 (63.1)

Reference

Reference

Mexico

40 (25.5)

1.16

0.59–2.29

0.667

1.19

0.54–2.69

0.659

Other

17 (10.8)

2.11

0.96–4.66

0.065

2.50

1.05–5.98

0.039

Missing

1 (0.6)

      
 

Medulloblastoma

Size for gestational age

< 10th percentile

27 (12.4)

2.09

1.10–3.96

0.024

3.12

1.56–6.24

0.001

10th–90th percentile

164 (75.6)

Reference

Reference

> 90th percentile

24 (11.1)

1.11

0.52–2.38

0.782

1.01

0.46–2.21

0.984

Missing

2 (0.9)

      
  1. aAdjusted for birth year, sex, maternal race/ethnicity, maternal education, tumor malignancy.
  2. bBonferroni corrected reference P values: 0.003 for an experiment-wide significance of 0.05.