Table 1 Characteristics of the matched study population.
Escalation (n = 164) | Control (n = 328) | p | |
---|---|---|---|
Age, years | 59.5 ± 10.0 | 58.8 ± 10.6 | 0.50 |
Men | 123 (75.0) | 254 (7.4) | 0.62 |
Risk factor Hypertension Diabetes mellitus Chronic kidney disease Atrial fibrillation | 99 (60.4) 32 (19.5) 8 (4.9) 4 (2.4) | 196 (59.8) 68 (20.7) 14 (4.3) 10 (3.0) | 0.93 0.77 0.86 0.80 |
Vascular disease Coronary artery disease Ischaemic stroke Peripheral artery disease Carotid artery disease Aortic disease | 146 (89.2) 14 (8.4) 1 (0.6) 2 (1.2) 1 (0.6) | 296 (90.4) 27 (8.1) 1 (0.3) 3 (0.9) 1 (0.3) | 0.93 |
Acute coronary syndrome | 78 (47.6) | 156 (47.6) | > 0.99 |
Body mass index, kg/m2 | 25.0 (23.4, 26.9) | 24.7 (23.2, 26.9) | 0.62 |
Number of diseased coronary vessels 0 1 2 3 | 7 (4.3) 69 (42.1) 45 (27.4) 43 (26.2) | 12 (3.7) 140 (42.7) 91 (27.7) 85 (25.9) | 0.98 |
LDL-C | |||
Baseline, mg/dL Range, mg/dL | 80 (74, 89) (2.07 [1.91, 2.30] mmol/L) 55–98 (1.42–2.53 mmol/L) | 79 (73, 88) (2.04 [1.89, 2.28] mmol/L) 55–99 (1.42–2.56 mmol/L) | 0.50 |
Follow-up, mg/dL Range, mg/dL | 65 (54, 73) (1.68 [1.40, 1.89] mmol/L) 35–115 (0.91–2.97 mmol/L) | 74 (65, 83) (1.91 [1.68, 2.15] mmol/L) 31–144 (0.80–3.72 mmol/L) | < 0.001 |
Percent change Achievement of < 55 mg/dL (1.4 mmol/L) | -20.9 (-34.3, -6.7) 46 (28.0) | -6.3 (-16.7, 6.8) 20 (6.1) | < 0.001 < 0.001 |