Figure 7
From: Discovery, optimization, and evaluation of non-bile acid FXR/TGR5 dual agonists
(a) Induction of SHP mRNA in mice liver by 20p and 20q following a single oral dose (100 mg/kg), compared with fexaramine 7 (100 mg/kg). (b) Induction of SHP mRNA in mice liver by 20p and 20q (10, 30 mg/kg). #p < 0.05, ##p < 0.01, significant difference from a control group, as analyzed by Student’s t-test., **p < 0.01 significant difference from a control group, as analyzed by Dunnett’s multiple comparison test. n = 5, control n = 10. (c) Repression of CYP7A1 in mice liver by 20p and 20q following a single oral dose (10, 30 mg/kg). **p < 0.01 significant difference from the control group, as analyzed by Dunnett’s multiple comparison test. n = 5, control n = 10.
