Figure 4

Canonical pathways enriched by proteins and transcripts significantly altered in ULMs from Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) and non-syndromic (NS) patients. Heatmap reflects the top 10 canonical pathways predicted as activated (positive z-score) or inhibited (negative z-score) based on proteins and transcripts significantly altered between HLRCC and non-syndromic ULMs (LIMMA adjusted p < 0.01). Pathways colored white not among top pathways predicted to be activated or inhibited in protein or transcript level data. Functional enrichment and causal analyses performed using Ingenuity Pathway Analysis¹⁵.