Figure 1
From: MicroRNA-138 suppresses glioblastoma proliferation through downregulation of CD44
Downregulation of miR-138 in glioblastoma (GBM) patient specimens. (A) Principal component analyses (PCA) on miRNA expression profiling obtained by NanoString miRNA Expression Analysis from 9 GBM patients and 4 negative control samples. As a quality control, PCA plot clearly classified the samples into two groups. (B) Volcano plot reveals down-regulation of miR-138 in an inverse correlation with miR-21. (C) Expression of miR-138 in GBM samples (0.009915 ± 0.003592, n = 9) compared to negative control samples (0.3525 ± 0.08532, n = 4) analyzed by qRT-PCR using TaqMan individual miRNA assay. (D) The Cancer Genome Atlas Program (TCGA) database shows that miR-138 expression is downregulated in glioblastoma (GBM) compared to normal tissues. All error bars indicates standard deviations, and Student t-test was used to determine the significance in difference between the two groups. ***p < 0.001.
