Figure 10
Levels of Ate1 mRNA are significantly lower in several types of neurodegenerative diseases. ALS: amyotrophic lateral sclerosis, comparing mouse microglia sorted from whole spinal cord of control and late stage TDP-43 proteinopathy, calculated from the public GSE109171 RNAseq data set75 normalized to \(\beta\)-actin. AD: Alzheimer’s disease, comparing laser captured human hippocampal gray matter of normal brain and severe AD patients, calculated from the public GSE28146 microarray data set76 using RMA method. PD: Parkinson’s disease, comparing laser-captured human dopaminergic neurons in substantia nigra of normal brain and PD patients, calculated from the public GSE20141 microarray data set77 using RMA method. Plot showing relative Ate1 mRNA expression levels. Calculation was performed in log2 unit and plotted in linear fashion. The error bars represent SEM and the p-values are from Welch’s t-test.
