Table 4 Regression model with Non Motor Symptom Scale domains as predictors of quality of life (measured by the PDQ-8 scale).

From: Cross-sectional analysis of the Parkinson’s disease Non-motor International Longitudinal Study baseline non-motor characteristics, geographical distribution and impact on quality of life

Parameters

Europe (n = 1327)

Americas (n = 208)

India and Japan (n = 72)

Entire cohort (n = 1607)

Model

R2 = 0.651, p < 0.001

R2 = 0.390, p < 0.001

R2 = 0.100, p = 0.064

R2 = 0.357, p < 0.001

NMSS domains

β*

p

β*

p

β*

p

β*

p

Cardiovascular/falls

0.076

 < 0.001

0.016

0.805

N/A

N/A

0.070

 < 0.001

Sleep/fatigue

0.173

0.001

0.065

0.354

0.047

0.758

0.143

0.002

Mood/apathy

0.288

 < 0.001

0.424

 < 0.001

0.267

0.080

0.308

 < 0.001

Perceptual/hallucinations

0.084

 < 0.001

0.041

0.511

N/A

N/A

0.077

 < 0.001

Memory/attention

0.154

 < 0.001

0.042

0.558

N/A

N/A

0.125

0.001

Gastrointestinal

0.110

 < 0.001

0.075

0.238

N/A

N/A

0.109

 < 0.001

Urinary

0.037

0.127

− 0.058

0.372

N/A

N/A

0.100

 < 0.001

Sexual

0.004

0.860

0.080

0.200

N/A

N/A

0.002

0.913

Miscellaneous

0.039

0.087

0.184

0.003

0.046

0.713

0.029

0.186

  1. NMSS Non Motor Symptoms Scale, N/A not applicable (factor not associated with PDQ-8 scores in a univariate model); β* standardised β. Only domains which were significantly associated with PDQ-8 scores in a univariate model were included in the respective analyses.
  2. P-values in bold are significant (p ≤ 0.05).
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