Figure 8 | Scientific Reports

Figure 8

From: The heat shock response, determined by QuantiGene multiplex, is impaired in HD mouse models and not caused by HSF1 reduction

Figure 8

Analysis of the heat shock response in the striatum of R6/2 mice at 12 weeks of age. The expression of heat shock genes was measured using the QuantiGene 16-plex assay in the striatum of wild-type and R6/2 mice at 11–12 weeks of age that had been treated with vehicle or NVP-HSP990. The NVP-HSP990 treated samples were normalised to the corresponding wild-type vehicle treated samples. N = 6–9/genotype/treatment. Statistical analysis was by two-way ANOVA with Bonferroni correction for multiple comparisons. Mean ± SEM. ***p ≤ 0.001. Test statistical values can be found in Supplementary Table S15 online. WT wild-type.

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