Table 2 Correlations between ENE in ALN and clinicopathological parameters.

From: Prognostic value of extranodal extension in axillary lymph node-positive breast cancer

Variables

No. of patients (%)

ENE

Univariable analysis

Multivariable analysis

Negative

Positive

OR

95% CI

p-value

OR

95% CI

p-value

Total population

 

402 (100)

244 (60.7%)

158 (39.3%)

      

Median age (Y)

 

52 (30–83)

50 (30–80)

54 (32–83)

      

T stage

      

0.465

   
 

T1

119 (29.6)

70 (17.4)

49 (12.2)

1

   
 

T2

261 (64.9)

162 (40.3)

99 (24.6)

0.873

0.561–1.359

0.547

   
 

T3

22 (5.5)

12 (3.0)

10 (2.5)

1.190

0.477–2.973

0.709

   

Histological grade

2

207 (51.5)

115(28.6)

92 (22.9)

1

   

3

195 (48.5)

130 (32.3)

65 (16.2)

1.632

1.089–2.445

0.018

0.559

0.347–0.889

0.016

N stage

      

 < 0.001

  

 < 0.001

 

1

107 (26.6)

87 (21.6)

20 (5.0)

1

   
 

2

191 (47.5)

119 (29.6)

72 (17.9)

2.574

1.459–4.451

0.001

2.456

1.360–4.434

0.003

 

3

104 (25.9)

38 (9.5)

66 (16.4)

7.877

4.194–14.796

 < 0.001

7.301

3.618–14.735

 < 0.001

ER status

Negative

96 (23.9)

63 (15.7)

33 (8.2)

1

   

Positive

306 (76.1)

181 (45.0)

125 (31.1)

0.758

0.470–1.224

0.258

   

PR status

Negative

121 (30.1)

78 (19.5)

43 (10.6)

1

   

Positive

281 (69.9)

166 (41.3)

115 (28.6)

0.796

0.512–1.238

0.331

   

HER2 status

Negative

307 (76.4)

180 (44.8)

127 (31.6)

1

   

Positive

95 (23.6)

64 (15.9)

31 (7.7)

1.457

0.897–2.367

0.129

   

Lympho-vascular invasion

Negative

206 (51.2)

142 (35.3)

64 (15.9)

1

   

Positive

196 (48.8)

102 (25.4)

94 (23.4)

2.045

1.361–3.072

0.001

1.258

0.793–1.994

0.330

Molecular subtype

Luminal-A like

72 (17.9)

37 (9.2)

35 (8.7)

1

   

Luminal-B like

182 (45.3)

114 (28.4)

68 (16.9)

0.631

0.363–1.094

0.101

0.661

0.361–1.211

0.180

HER2-overexpression

52 (12.9)

36 (9.0)

16 (3.9)

0.470

0.222–0.993

0.048

0.418

0.179–0.977

0.044

Triple negative breast cancer

45 (11.2)

31 (7.7)

14 (3.5)

0.477

0.218–1.044

0.064

0.566

0.232–1.381

0.211

Others

51 (12.7)

/

/

      
  1. ER estrogen receptor; PR progesterone receptor; HER2 human epidermal growth factor receptor 2; ENE extranodal extension.