Table 4 Correlations between ENE in ALN and DRFS and OS.

From: Prognostic value of extranodal extension in axillary lymph node-positive breast cancer

Variables

Disease recurrence free survival

Overall survival

Univariable analysis

Multivariable analysis

Univariable analysis

Multivariable analysis

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

Median age (Y)

 ≤ 52

        

 > 52

0.715 (0.491–1.041)

0.080

  

0.660 (0.480–0.908)

0.011

2.081 (1.0814.006)

0.028

T stage

 

0.385

   

0.004

  

T1

  

  

T2

1.526 (0.970–2.402)

0.067

  

3.213 (1.254–8.230)

0.015

2.932 (1.122–7.661)

0.028

T3

1.920 (0.863–4.273)

0.110

  

3.416 (0.814–14.330)

0.093

2.352 (0.542–10.218)

0.254

Histologic grade

2

        

3

0.914 (0.753–1.110)

0.364

  

0.777 (0.568–1.062)

0.114

  

N stage

 

 < 0.001

   

 < 0.001

  

1

  

  

2

1.367 (0.776–2.411)

0.279

1.201 (0.671–2.148)

0.537

1.893 (0.610–5.875)

0.269

1.702 (0.534–5.424)

0.369

3

3.716 (2.180–6.336)

 < 0.001

2.781 (1.501–5.154)

0.001

7.683 (2.673–22.086)

 < 0.001

4.677 (1.440–15.192)

0.010

No. of removed axillary lymph nodes

 ≤ 20

        

 > 20

0.920 (0.762–1.112)

0.389

      

Median metastatic tumor diameter (cm)

 ≤ 0.7

        

 > 0.7

1.817 (1.212–2.725)

0.004

1.186 (0.760–1.851)

0.452

1.946 (0.990–3.825)

0.053

0.896 (0.428–1.875)

0.771

ENE

Negative

        

Positive

2.126 (1.453–3.112)

 < 0.001

1.745 (1.152–2.642)

0.009

2.505 (1.337–4.693)

0.004

1.639 (0.824–3.260)

0.159

ER status

Negative

        

Positive

1.130 (0.910–1.403)

0.267

  

1.502 (1.097–2.058)

0.011

0.908 (0.297–2.779)

0.866

PR status

Negative

        

Positive

1.214 (0.987–1.492)

0.066

0.858 (0.540–1.364)

0.519

1.463 (1.071–1.999)

0.017

0.678 (0.232–1.978)

0.477

HER2 status

Negative

        

Positive

0.758 (0.613–0.937)

0.010

1.743 (1.085–2.799)

0.022

0.680 (0.494–0.938)

0.019

1.500 (0.708–3.180)

0.290

Peri lymph node vascular invasion

No

        

Yes

1.405 (0.958–2.060)

0.082

0.852 (0.559–1.298)

0.456

2.020 (1.059–3.855)

0.033

1.169 (0.571–2.392)

0.670

  1. ER estrogen receptor; PR progesterone receptor; HER2 human epidermal growth factor receptor 2; ENE extranodal extension.