Table 4 Correlations between ENE in ALN and DRFS and OS.
From: Prognostic value of extranodal extension in axillary lymph node-positive breast cancer
Variables | Disease recurrence free survival | Overall survival | ||||||
---|---|---|---|---|---|---|---|---|
Univariable analysis | Multivariable analysis | Univariable analysis | Multivariable analysis | |||||
HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
Median age (Y) | ||||||||
≤ 52 | ||||||||
> 52 | 0.715 (0.491–1.041) | 0.080 | 0.660 (0.480–0.908) | 0.011 | 2.081 (1.0814.006) | 0.028 | ||
T stage | 0.385 | 0.004 | ||||||
T1 | – | – | – | – | ||||
T2 | 1.526 (0.970–2.402) | 0.067 | 3.213 (1.254–8.230) | 0.015 | 2.932 (1.122–7.661) | 0.028 | ||
T3 | 1.920 (0.863–4.273) | 0.110 | 3.416 (0.814–14.330) | 0.093 | 2.352 (0.542–10.218) | 0.254 | ||
Histologic grade | ||||||||
2 | ||||||||
3 | 0.914 (0.753–1.110) | 0.364 | 0.777 (0.568–1.062) | 0.114 | ||||
N stage | < 0.001 | < 0.001 | ||||||
1 | – | – | – | – | ||||
2 | 1.367 (0.776–2.411) | 0.279 | 1.201 (0.671–2.148) | 0.537 | 1.893 (0.610–5.875) | 0.269 | 1.702 (0.534–5.424) | 0.369 |
3 | 3.716 (2.180–6.336) | < 0.001 | 2.781 (1.501–5.154) | 0.001 | 7.683 (2.673–22.086) | < 0.001 | 4.677 (1.440–15.192) | 0.010 |
No. of removed axillary lymph nodes | ||||||||
≤ 20 | ||||||||
> 20 | 0.920 (0.762–1.112) | 0.389 | ||||||
Median metastatic tumor diameter (cm) | ||||||||
≤ 0.7 | ||||||||
> 0.7 | 1.817 (1.212–2.725) | 0.004 | 1.186 (0.760–1.851) | 0.452 | 1.946 (0.990–3.825) | 0.053 | 0.896 (0.428–1.875) | 0.771 |
ENE | ||||||||
Negative | ||||||||
Positive | 2.126 (1.453–3.112) | < 0.001 | 1.745 (1.152–2.642) | 0.009 | 2.505 (1.337–4.693) | 0.004 | 1.639 (0.824–3.260) | 0.159 |
ER status | ||||||||
Negative | ||||||||
Positive | 1.130 (0.910–1.403) | 0.267 | 1.502 (1.097–2.058) | 0.011 | 0.908 (0.297–2.779) | 0.866 | ||
PR status | ||||||||
Negative | ||||||||
Positive | 1.214 (0.987–1.492) | 0.066 | 0.858 (0.540–1.364) | 0.519 | 1.463 (1.071–1.999) | 0.017 | 0.678 (0.232–1.978) | 0.477 |
HER2 status | ||||||||
Negative | ||||||||
Positive | 0.758 (0.613–0.937) | 0.010 | 1.743 (1.085–2.799) | 0.022 | 0.680 (0.494–0.938) | 0.019 | 1.500 (0.708–3.180) | 0.290 |
Peri lymph node vascular invasion | ||||||||
No | ||||||||
Yes | 1.405 (0.958–2.060) | 0.082 | 0.852 (0.559–1.298) | 0.456 | 2.020 (1.059–3.855) | 0.033 | 1.169 (0.571–2.392) | 0.670 |