Table 5 Correlations between ENE cutoffs and prognosis.

From: Prognostic value of extranodal extension in axillary lymph node-positive breast cancer

Variables

Disease recurrence free survival

Overall survival

Univariable analysis

Multivariable analysis

Univariable analysis

Multivariable analysis

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

Median age (Y)

 ≤ 52

        

 > 52

0.645 (0.390–1.066)

0.087

  

0.532 (0.235–1.205)

0.132

  

T stage

 

0.794

   

0.346

  

T1

  

  

T2

1.533 (0.867–2.712)

0.142

  

3.543 (1.052–11.926)

0.041

3.324 (0.939–11.769)

0.063

T3

1.075 (0.311–3.719)

0.909

  

3.210 (0.534–19.287)

0.202

2.486 (0.411–15.027)

0.321

Histologic grade

2

        

3

0.773 (0.497–0.999)

0.049

1.072 (0.606–1.894)

0.812

0.686 (0.461–1.022)

0.064

  

N stage

 

0.002

   

0.003

  

1

  

  

2

0.694 (0.269–1.793)

0.451

  

1.726 (0.208–14.339)

0.614

  

3

2.280 (0.966–5.382)

0.060

  

6.051 (0.807–45.370)

0.080

  

No. of removed axillary lymph nodes

 ≤ 20

        

 > 20

0.829 (0.646–1.065)

0.142

  

0.871 (0.588–1.290)

0.492

  

Median metastatic tumor diameter (cm)

 ≤ 0.7

        

 > 0.7

2.183 (1.190–4.006

0.012

1.907 (1.007–3.610)

0.047

1.642 (0.654–4.124)

0.291

  

No. of ENE foci

1–2

        

 > 2

2.050 (1.224–3.434)

0.006

2.080 (1.220–3.545)

0.007

2.743 (1.244–6.049)

0.012

0.328 (0.143–0.751)

0.008

CD-ENE

 ≤ 3 mm

        

 > 3 mm

1.138 (0.668–1.938)

0.634

  

1.179 (0.514–2.706)

0.697

  

PD-ENE

 ≤ 2 mm

        

 > 2 mm

1.144 (0.695–1.883)

0.598

  

0.714 (0.321–1.591)

0.410

  

ER status

Negative

        

Positive

1.732 (1.042–1.806)

0.024

1.190 (0.483–2.930)

0.706

1.709 (1.143–2.556)

0.009

1.831 (0.479–7.003)

0.377

PR status

Negative

        

Positive

1.547 (1.174–2.039)

0.002

0.487 (0.207–1.147)

0.100

1.774 (1.189–2.649)

0.005

2.391 (0.687–8.328)

0.171

HER2 status

        

Negative

        

Positive

0.690 (0.512–0.931)

0.015

1.736 (0.859–3.507)

0.125

0.640 (0.419–0.979)

0.040

0.934 (0.334–2.612)

0.897

Peri lymph node vascular invasion

No

        

Yes

1.067 (0.634–1.796)

0.808

  

1.047 (0.470–2.335)

0.910

  
  1. ENE extranodal extension; PD-ENE perpendicular diameter of extra-nodal extension; CD-ENE, circumferential diameter of extra-nodal extension.ER estrogen receptor; PR progesterone receptor; HER2 human epidermal growth factor receptor 2.