Table 5 Correlations between ENE cutoffs and prognosis.
From: Prognostic value of extranodal extension in axillary lymph node-positive breast cancer
Variables | Disease recurrence free survival | Overall survival | ||||||
---|---|---|---|---|---|---|---|---|
Univariable analysis | Multivariable analysis | Univariable analysis | Multivariable analysis | |||||
HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
Median age (Y) | ||||||||
≤ 52 | ||||||||
> 52 | 0.645 (0.390–1.066) | 0.087 | 0.532 (0.235–1.205) | 0.132 | ||||
T stage | 0.794 | 0.346 | ||||||
T1 | – | – | – | – | ||||
T2 | 1.533 (0.867–2.712) | 0.142 | 3.543 (1.052–11.926) | 0.041 | 3.324 (0.939–11.769) | 0.063 | ||
T3 | 1.075 (0.311–3.719) | 0.909 | 3.210 (0.534–19.287) | 0.202 | 2.486 (0.411–15.027) | 0.321 | ||
Histologic grade | ||||||||
2 | ||||||||
3 | 0.773 (0.497–0.999) | 0.049 | 1.072 (0.606–1.894) | 0.812 | 0.686 (0.461–1.022) | 0.064 | ||
N stage | 0.002 | 0.003 | ||||||
1 | – | – | – | – | ||||
2 | 0.694 (0.269–1.793) | 0.451 | 1.726 (0.208–14.339) | 0.614 | ||||
3 | 2.280 (0.966–5.382) | 0.060 | 6.051 (0.807–45.370) | 0.080 | ||||
No. of removed axillary lymph nodes | ||||||||
≤ 20 | ||||||||
> 20 | 0.829 (0.646–1.065) | 0.142 | 0.871 (0.588–1.290) | 0.492 | ||||
Median metastatic tumor diameter (cm) | ||||||||
≤ 0.7 | ||||||||
> 0.7 | 2.183 (1.190–4.006 | 0.012 | 1.907 (1.007–3.610) | 0.047 | 1.642 (0.654–4.124) | 0.291 | ||
No. of ENE foci | ||||||||
1–2 | ||||||||
> 2 | 2.050 (1.224–3.434) | 0.006 | 2.080 (1.220–3.545) | 0.007 | 2.743 (1.244–6.049) | 0.012 | 0.328 (0.143–0.751) | 0.008 |
CD-ENE | ||||||||
≤ 3 mm | ||||||||
> 3 mm | 1.138 (0.668–1.938) | 0.634 | 1.179 (0.514–2.706) | 0.697 | ||||
PD-ENE | ||||||||
≤ 2 mm | ||||||||
> 2 mm | 1.144 (0.695–1.883) | 0.598 | 0.714 (0.321–1.591) | 0.410 | ||||
ER status | ||||||||
Negative | ||||||||
Positive | 1.732 (1.042–1.806) | 0.024 | 1.190 (0.483–2.930) | 0.706 | 1.709 (1.143–2.556) | 0.009 | 1.831 (0.479–7.003) | 0.377 |
PR status | ||||||||
Negative | ||||||||
Positive | 1.547 (1.174–2.039) | 0.002 | 0.487 (0.207–1.147) | 0.100 | 1.774 (1.189–2.649) | 0.005 | 2.391 (0.687–8.328) | 0.171 |
HER2 status | ||||||||
Negative | ||||||||
Positive | 0.690 (0.512–0.931) | 0.015 | 1.736 (0.859–3.507) | 0.125 | 0.640 (0.419–0.979) | 0.040 | 0.934 (0.334–2.612) | 0.897 |
Peri lymph node vascular invasion | ||||||||
No | ||||||||
Yes | 1.067 (0.634–1.796) | 0.808 | 1.047 (0.470–2.335) | 0.910 |