Figure 1
From: Mexiletine-like cellular electrophysiological effects of GS967 in canine ventricular myocardium
Effects of 1 µM GS967 (A,C) and 40 µM mexiletine (B,D) on INaL under conventional voltage clamp conditions using test pulses of 2 s duration clamped to −20 mV from the holding potential of −120 mV. At the end of each experiment the cells were superfused with 20 µM TTX to dissect the remaining INaL. Dashed lines indicate zero current level. (A,B) Representative superimposed analogue records. (C,D) Average INaL densities (measured at 50 ms) and integrals (measured from 20 ms to 2 s). Symbols and bars are mean ± SEM, small dots represent individual data, numbers in parentheses indicate the number of myocytes studied, asterisks denote significant differences between data of the pre-drug control and the GS967- or mexiletine-treated groups.
