Figure 2

Sequence and structure of human nucleophosmin (UniprotKB: P06748). Windowed charge scores (A), predicted fold propensities (B), phosphorylation sites (C), and Pfam domains (D) are shown, for unmodified and phosphorylated nucleophosmin. The Pfam domains correspond with predicted structured domains, for which solved structure is available, and labelled core domain and C-terminal (C-term) domain. (E) Using the same colour-coding as fold propensity prediction (yellow/folded and blue/unfolded), a cartoon of a core domain monomer is shown against a surface of the remaining 4 monomers in a pentamer unit (PDB⁴² id 4nm8¹⁹). Known phosphorylation sites are indicated with green spacefill and residue numbers. (F) Also with the yellow and blue colour-coding for predicted structural order from the phosIDP server, the C-terminal domain is drawn (first model from 2vxd²¹). Known phosphorylation sites for this sequence are shown, along with an indication of the N- and C-terminal ends of the domain.