Table 1 Cohort characteristics and biomarker values in the clinical validation.

From: Highly specific and ultrasensitive plasma test detects Abeta(1–42) and Abeta(1–40) in Alzheimer’s disease

 

Cohort

Controls (42)

AD (43)

Total (85)

p

 

Sex, M/F

25/17

21/22

39/46

0.33

M (SD)

Age, y

61.7 (5)

68.1 (6)

64.9 (6)

 < 0.001

M (SD)

MMSE

27.2 (3)

22.0 (5)

24.6 (5)

 < 0.001

n

 

42

42

84

 

M (IQR)

CSF Tau (pg/mL)

223 (117)

615 (399)

427 (395)

 < 0.001

n

 

42

43

85

 

M (IQR)

CSF P-tau (pg/mL)

39 (15)

89 (37)

63 (36)

 < 0.001

n

 

41

43

84

 

M (IQR)

CSF Abeta 42 (pg/mL)

1132 (308)

658 (153)

804 (475)

 < 0.001

n

 

42

43

85

 
  1. Abeta, Amyloid beta; CSF, Cerebrospinal fluid; ELISA, Enzyme-Linked Immuno Sorbent Assay; MMSE, Mini-Mental State Examination; pTau, phosphorylated tau. M (SD) shows the mean value and standard deviation. M (IQR) shows the median value and interquartile range. P values show the difference between the CSF Aβ negative and the CSF Aβ positive group. Significant p-values are shown in italics (p < 0.05).