Table 2 Whole and subfield volumes of the affected and contralateral hippocampus of GAD-TLE patients compared with those of niTLE and HC.

From: Volumetric and shape analysis of the hippocampus in temporal lobe epilepsy with GAD65 antibodies compared with non-immune epilepsy

Hippocampal Subfields

Proportion between (%)

Affected hippocampus (volume, mm3)

     

Contralateral hippocampus

Affected/non-affected hippocampus

GAD-TLE (n:10)† [Me, IQR]

niTLE (n:8)† [Me, IQR]

HC (n:16)† [Me, IQR]

Kruskal wallis test (p)

Bonferroni post hoc

GADTLE (n:6)†[Me, IQR]

niTLE (n:8)†[Me, IQR]

Bonferroni post hoc

GAD65ab

niTLE

GAD65ab vs niTLE

GAD65ab vs HC

niTLE vs HC

GAD65-niTLE

niTLE-HC

Presubiculum

 − 8.9

 − 25.2

174.4 (85.10)

146.0 (35.0)

198.8 (51.1)

0.003

NS

NS

 < 0.0001*

191.39 (78.89)

195.18 (38.5)

NS

NS

Parasubiculum

 − 7.3

 − 28.3

34.0 (12.12)

30.9 (10.6)

41.7 (10.2)

0.02

NS

NS

0.016*

36.7(9.08)

43.13(8.59)

NS

NS

Subiculum

 − 8.35

 − 30.6

251.1(96.19)

202.1 (27.0)

274.3 (49.8)

0.0004

0.004*

NS

 < 0.0001*

273.95 (93.89)

291.09 (36.05)

NS

NS

CA1

 − 11.7

 − 36.9

372.9(159.28)

284.0 (55.8)

429.8 (58.1)

0.0006

0.002*

NS

 < 0.0001*

422.27 (107.6)

450.11 (31.86)

NS

NS

CA3

5.2

 − 33.9

142.4 (41.07)

94.0 (28.7)

134.5 (28.7)

0.0013

0.001*

NS

0.001*

135.45 (44.46)

142.39 (27.50)

NS

NS

CA4

 − 10.4

 − 35.5

164.1 (53.47)

116.6 (18.6)

170.6 (20.9)

0.0003

0.001*

NS

0.001*

183.20(48.35)

180.9 (12.71)

NS

NS

GC-ML-DG

 − 13.9

 − 35.3

186.6 (59.64)

134.4 (20.8)

198.4 (25.3)

0.0003

0.001*

NS

 < 0.0001*

216.73 (61.41)

207.75 (16.0)

NS

NS

HATA

 − 6.83

 − 15.5

42.1 (10.97)

34.7 (8.1)

38.8 (6.4)

NS

NS

NS

NS

45.22 (14.14)

41.05 (9.64)

NS

NS

Fimbria

 − 11.44

 − 17.6

49.3 (24.96)

50.4 (19.4)

53.7 (12.8)

NS

NS

NS

NS

55.67(24.87)

61.14 (13.64)

NS

NS

Molecular layer

 − 13.88

 − 36.1

336.1(113.34)

253.2 (45.7)

392.6 (47.5)

0.0002

0.001*

NS

 < 0.0001*

390.27 (101.29)

396.49 (40.85)

NS

NS

Hippocampal fissure

 − 3.32

 − 16.5

95.9 (26.7)

80.5 (16.3)

84.2 (24.1)

NS

NS

NS

NS

99.24 (37.28)

96.53 (18.70)

NS

NS

Hippocampal tail

 − 4.27

 − 30.7

375.5 (83.48)

264.2 (24.9)

372.5 (41.1)

0.0011

0.002*

NS

 < 0.0001*

392.23 (123.53)

381.56 (91.66)

NS

NS

Whole Hippocampus

 − 15.31

 − 35.7

2070.70 (682.0)

1574.1(276.3)

2292.7 (206.1)

0.0003

0.001*

NS

 < 0.0001*

2445.12 (596.72)

2446.75 (230.72)

NS

NS

  1. †n number of hippocampus included in the analysis, CA1-2–3-4 Cornu ammonis areas 1,2–3,4, GC-ML-DG granule cells in the molecular layer of the dentate gyrus, HATA hippocampus-amygdala-transition-area. NS non-significant, Me median, IQR interquartile range.
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