Figure 3
From: Multi-step screening of neoantigens’ HLA- and TCR-interfaces improves prediction of survival
Stratification of cancer patients according to TMB analysis, NetMHCpan analysis, and the Ancer pipeline. TCGA bladder cancer patients were separated based on their median TMB (a,b), NetMHCpan neoepitope burden (c,d), or Ancer pipeline-defined neoepitope burden (e,f). Median disease-free survival (DFS) (a,c,e) and median overall survival (OS) (b,d,f) were evaluated with the Kaplan–Meier estimator. Double-ended arrows define the differences in median survival times between the groups for each of the analyses. Statistical significance was evaluated using the log-rank test. The largest differential in median overall survival, 70 months, was obtained with the Ancer pipeline and was more than double the difference in median overall survival observed when stratifying patients using NetMHCpan (34 months).
