Figure 1

Methylome profiling (heatmaps: blue: low, yellow: high DNA methylation). (a) Hierarchical cluster analysis of DNA methylation data of 420 CpG loci differentially methylated between short-term (red boxes on top of heatmap) and long-term relapse-free survivors (green boxes). p < 4 × 10−4, σ/σmax>0.3; normalized presentation: mean = 0, scale: − 0.3–0.3. (b) Classification of short-term (red boxes on top of the heatmap) and long-term relapse-free survivors (green boxes) based on the DNA methylation pattern (random tree).