Table 2 Molecular pathological characterization (Sequencing and FISH analyses).
Category | Early relapse (n = 49) | Late relapse (n = 40) |
|---|---|---|
EGFR/KRAS wildtype | 25 (51%) | 13 (33%) |
KRAS exon 2 or 3 mutated (point mutations) | 21 (43%) | 17 (43%) |
EGFR exon 18+20 mutated (point mutations) | 0 | 1 (3%) |
EGFR exon 19 mutated (deletions or duplication) | 1 (2%) | 5 (13%) |
EGFR exon 20 mutated (point mutation or duplication) | 0 | 2 (5%) |
EGFR exon 21 mutated (point mutations) | 2 (4%) | 2 (5%) |
ALK/RET/ROS1 FISH wildtype | 49 (100%) | 40 (100%) |
ALK rearrangement | 0 | 0 |
RET rearrangement | 0 | 0 |
ROS1 rearrangement | 0 | 0 |
PD-L1 FISH wildtype | 49 (100%) | 39 (98%) |
PD-L1 amplification | 0 | 1 (2%) |
