Table 5 Activity data for 14 kinase targets tested at different concentration of CDDP.

From: Elucidating direct kinase targets of compound Danshen dropping pills employing archived data and prediction models

#

Kinase

Gene

Gene ID

Activity data 1 (%a)

Activity data 2 (%a)

1

Aurora-B(h)b

AURKB

9212

56

28

2

CaMKIIγ(h)

CAMK2G

818

64

86

3

CK1γ3(h)b

CSNK1G3

1456

58

23

4

CK2α1(h)b

CSNK2A1

1457

65

47

5

CK2α2(h)b

CSNK2A2

1459

64

43

6

CLK1(h)

CLK1

1195

4

4

7

FGFR1(h)b

FGFR1

2260

69

43

8

Fms(h)

CSF1R

1436

59

58

9

Fyn(h)

FYN

2534

63

63

10

GSK3β(h)b

GSK3B

2932

56

39

11

Met(h)b

MET

4233

43

8

12

Pim-1(h)b

PIM1

5292

69

18

13

Ret(h)

RET

5979

61

70

14

Syk(h)b

SYK

6850

63

2

  1. aThe lower the value, the stronger the binding activity.
  2. bThe kinase with potential dose-dependent effect. Activity data 1 and 2 is the activity data of kinase targets tested at 25 µg/mL and 250 µg/mL concentration of CDDP, respectively.
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