Figure 1
From: Dermal bacterial LPS-stimulation reduces susceptibility to intradermal Trypanosoma brucei infection
Enhanced abundance of Csf1r-EGFP + mononuclear phagocytes (MNP) in the dermis of Csf1r-EGFP+ mice after intradermal (ID) injection with CSF1-Fc. (A) Csf1r-EGFP reporter mice were injected ID with CSF1-Fc, or PBS as a control, for three days and 24 h after the final injection the ears were removed and viewed using a 2-photon microscope. Images show EGFP + MNP (green, arrowheads) and background collagen signal (purple) in the dermis. Arrows, auto-fluorescent hair follicles. (B) The numbers of EGFP + MNP in the dermis local to the injection site were significantly increased after CSF1-Fc-treatment when compared to PBS-treated controls (P = 0.001, Student’s t-test; CSF1-Fc, n = 4; PBS, n = 3).
