Figure 3
From: Dermal bacterial LPS-stimulation reduces susceptibility to intradermal Trypanosoma brucei infection
ID LPS treatment decreases susceptibility to ID T. brucei infection. (A) Csf1r-EGFP reporter mice were injected ID with LPS, or PBS as a control, and 24 h later the abundance of EGFP + MNP cells in the dermis local to the injection site determined as in Fig. 1. Similar numbers of EGFP+ MNP were observed in the ear following ID LPS or PBS treatment (n = 2–3 mice/group). (B) Groups of C57BL/6 J mice were injected ID with LPS, or PBS as a control, and 24 h later injected with ID with a 1 × 105 dose of T. brucei STIB 247 parasites (n = 8 mice/group). Heatmap shows the log10 number of trypanosomes/mL of blood on each day after ID infection. Each row represents an individual mouse. UD = below detection limit of 5.4 log10 parasites/mL.
