Figure 4
From: RETRACTED ARTICLE: nAChRs gene expression and neuroinflammation in APPswe/PS1dE9 transgenic mouse
Presence of clusters of reactive astrocytes surrounding Aβ-deposits in APPswe/PS1dE9 mouse cortex and hippocampus (representative images). (A) Distribution of Aβ-deposits in cortex coronal section 50 µm of 24-months old AD (APPswe/PS1dE9) mouse (×10). (A1) Reactive astrocytes (×40). (A2) Distribution of Aβ-deposits, (×40). (A3) Cell nuclei (×40), arrows indicate the loss of cells in the same locality where there are Aβ-deposits, and the presence of reactive astrocytes around and between the Aβ plaques. (A4) Merged (A1,A2,A3). (B) Distribution of Aβ-deposits in hippocampus coronal section 50 µm of 24-month old AD (APPswe/PS1dE9) mouse (×10). (B1) Reactive astrocytes in granular layer of the gyrus dentate of hippocampus (×40). (B2) Distribution of Aβ-deposits, (×40). (B3) Cell nuclei (×40), arrows indicate the loss of cells in the same location where there are Aβ-deposits, and the localization of reactive astrocytes around and between the Aβ plaques. (B4) Merged (B1,B2,B3). Coronal section 50 µm. Anti-GFAP (red), anti-Aβ (green), bismencimide (blue). Bars 1 cm (A,B) and 0.5 cm (A1–A4, B1–B4).
