Table 3 Summary of treatment After ASSP therapy.

From: Artemisinin combination therapy fails even in the absence of Plasmodium falciparum kelch13 gene polymorphism in Central India

PCR

Drug

Study population (n)

Day-3 positive parasite

ETF (n)

LTF (n)

ACPR (n)

Recrudescence (n)

Re-infection (n)

PCR uncorrected

ASSP

180

9 (5%)

7a (3.9%)

12 (6.7%)

159 (88.3%)

–

–

PCR corrected

ASSP

180

9 (5%)

7a (3.9%)

10b (5.6%)

161 (89.4%)

10 (5.6%)

2 (1.1%)

  1. ACPR, ETF and LTF stand for adequate clinical parasitological response, early treatment failure and late treatment failure, respectively, whereas ASSP stand for artemisinin-sulfadoxine-pyrimethamine.
  2. aOne patient did not attain the adequate plasma DHA concentration and in another patient, we failed to adapt the in vitro culture for RSA assay.
  3. bInitially reappearance of infection was observed in 12 patients (6.7%), but analyses of msp1, msp2, and glurp gene confirmed that among those 12 patients, 10 (5.5%) were true recrudescence (LTF) case.
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