Table 5 Distribution of parasite phenotype and genotypes in day-3 positive parasites.

> 72 h (+) case	Plasma artesunate (nmol/L)		Parasite load on day-0 pd/µL	Parasite load on day-3 pd/µL	Fever on day 0 (°C)	Fever on day 3 (°C)	RSA_(0–3 h) (in %)	Treatment response (in h)		Kelch13 genotype	Atpase6 haplotype	Pfmdr1 haplotype	Pfcrt haplotype
	1.5 h	3 h						PCT	PC_1/2
Case1	4023	2361	19,368	237	39.6	38.1	2.4	96	6.2	Wild	LEAAS	YYSND	SVMNTNT
Case 2	4196	2147	8432	96	38.5	38	3.0	102	5.6	Wild	LEAAS	YFSND	CVIETNT
Case 3	3833	2051	21,641	356	38.7	38.1	2.1	108	5.6	Wild	LEAAS	YFSND	SVMNTST
Case 4	4077	1952	70,846	611	38.4	37.8	2.6	108	5.8	Wild	LEAAS	YFSND	SVMNTST
Case 5	4086	2052	56,855	123	38.8	37.5	1.7	96	5.3	Wild	LEAAS	YFSND	SVMNTST
Case 6	3981	2114	11,790	202	40.3	38.2	3.3	120	5.9	Wild	LEEAS	YFSND	SVMNTNT
Case 7	3591	1805	44,181	728	39.8	37.9	–	102	5.7	Wild	LEEAS	YFSND	SVMNTNT
Case 8	955	548	9716	455	38	37.5	0.9	108	5.7	Wild	LEAAS	YYSND	SVMNTST
Case 9	4258	2104	36,847	107	39.5	38	2	114	5.5	Wild	LEAAS	YFSND	CVIETNT

PCT represented Parasite clearance time (in h) and parasite clearance half-life was denoted as PC_1/2 (in h). We have presented parasite density as PD. Individual ex-vivo ring stage survivability of parasite isolates was represented as RSA_(0–3 h). Underline codons were mutant codon. In case 8, RSA_(0–3 h) was recorded 0.94% with PC_1/2 of 5.7 h while case 7 was failed to culture adaptation. The day-3 parasite load was ranging from 1.8 to 14.2% from that of day-0 parasitaemia.

Quick links

Search