Table 2 Antibacterial study of dextran sulfate sodium (DSS) nanoparticles of batch 3.

From: Formulation and evaluation of injectable dextran sulfate sodium nanoparticles as a potent antibacterial agent

Organisms

Concentration (CFUa/mL)

MIC (µg/mL)

Zone of inhibition (mm)

DSS nanoparticles

Ciprofloxacin (50 µg/mL)

Bacillus subtilis

2 × 10−5

150

23.5 ± 2

25.5 ± 1.2

Staphylococcus aureus

4 × 10−5

200

20.8 ± 1

25 ± 0.8***

Streptococcus pyogenes

4 × 10−3

250

24.6 ± 0.8

25.6 ± 0.9

Escherichia coli

3 × 10−5

150

26 ± 1.2

27 ± 1.6

Pseudomonas aeruginosa

2 × 10−3

200

21.8 ± 1

22.8 ± 1

Klebsiella pneumoniae

2 × 10−4

250

22 ± 2

24.16 ± 1.3

Proteus vulgaris

3 × 10−3

250

20.5 ± 0.9

22.16 ± 1.3*

  1. Each value is the mean of 6 batches with standard deviation.
  2. The statistical analyses were done using the Prism 9, Graph Pad Instat software system, USA.
  3. The test values were compared with the standard drug values using Dunnet’s post hoc test.
  4. ***Extremely significant at p ≤ 0.001when compared to DSS nanoparticles; *significant at p ≤ 0.01 when compared to DSS nanoparticles.
  5. aCFU colony forming unit.
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