Figure 1

Association of genetic variants of the HOXB locus with prostate cancer in combined ICPCG, NFPCS, and PLCO subjects. Association tests for 5517 HOXB locus variants within subjects of the combined study populations are positioned along the X-axis (chr17: 45,316,626–46,960,760 genomic interval (GRCh37/hg19)), illustrating − log₁₀ P values on the Y-axis. Horizontal black lines correspond to the genome-wide significance threshold of P = 5E−8 and to P = 0.05. Each data point depicts the result of a multiplicative logistic regression model (additive genetic model), with two-sided significance assessed using Wald tests. Variants depicted in blue are those that were also nominally significant in all three study populations separately (see Table 2). At bottom is a UCSC map of regional genes. Association results for each separate study population as well as for the combined study populations are given in Supplementary Table S1.