Table 3 Hemodynamics, pulmonary mechanics, blood gas data, and preload indicators for responders and nonresponders at each positive end-expiratory pressure (PEEP) level.

From: Effects of positive end-expiratory pressure on the predictability of fluid responsiveness in acute respiratory distress syndrome patients

Variable

PEEP 5

PEEP 10

PEEP 15

Responder (n = 16)

Nonresponders (n = 11)

Responder (n = 16)

Nonresponders (n = 11)

Responder (n = 16)

Nonresponders (n = 11)

HR (beats/min)

120 (22)

114 (22)

117 (23)

112 (24)

118 (22)

113 (22)

SAP (mmHg)

135 (32)

139 (29)

135 (34)

133 (25)

116 (25)

134 (28)

MAP (mm Hg)

84 (23)

90 (19)

85 (24)

86 (15)

73 (19)

88 (20)

CI (L/min/m2)

3.8 (1.15)

4.0 (1.22

3.8 (1.08

3.76 (1.09

3.51 (1.05)

3.88 (1.2)

SVI (mL/m2)

30.5 (7.4)

35.7 (9.7)

30.9 (7.3)

34.5 (9.7)

28.6 (7.5)

34.8 (9.5)

SVRI (dynes/s/cm5/m2)

1546 (470)

1571 (450)

1559 (517)

1612 (521)

1415 (411)

1571 (434)

PaO2 mmHg

60.0 (14.8)

71.8 (18.9)

80.8 (36.5)

92 (22)*

80.7 (46.7)

100.8 (34.3)*

PaO2/FiO2

91 (34.5)

134.2 (67.7)

117.1 (38.1)

168.3 (66.8)*

116.9 (48.9)

180.6 (65.3)*

PaCO2 mmHg

63.3 (22.7)

57.5 (15.8)

63.6 (23.4)

57.4 (16.3)

65 (22.1)

58.8 (17.3)

SaO2 (%)

83.1 (9.5)

89.6 (6.8)

90.6 (6.45)

95.1 (2.7)*

90.6 (5.3)

95.6 (2.7)*

Pplat (cmH2O)

21 (4.5)

18.9 (3.6)

24.7 (4.9)

23.5 (4.5)

32.2 (5.7)

29.5 (3.1)

Pmean (cmH2O)

10.8 (1.7)

9.7 (1.44)

15.4 (2.6)

14.7 (2.0)

21.1 (2.3)

20.1 (1.7)

Total PEEP (cm/H2O)

6.1 (1.2)

6.2 (0.8)

10.9 (1.4)

10.8 (0.6)

15.4 (0.7)

15.8 (0.9)

Crs (mL/cmH2O)

33.5 (16.7)

33.5 (15.8)

36.1 (15.8)

36.0 (16.0)

31.7 (14.8)

29.2 (14.5)

Driving pressure (Pplat-total PEEP) (cm/H2O)

14.3 (4.1)

14.2 (4.7)

13.0 (4.5)

14.1 (5.2)

15.5 (5.3)

16.4 (5.7)

SVV (%)

10.2 (5.4)

6.1 (3.8)*

11.2 (5.6)

6.5 (3.1)*

16.1 (7.5)

8.1) (3.0)*

PPV (%)

7.3 (4.1)

4.0 (2.4)*

7.0 (3.5)

5.1 (2.7)

12.1 (4.8)

6.2 (2.9)*

PPV/driving-P (%)

0.55 (0.32)

0.33 (0.27)*

0.64 (0.47)

0.6 (0.19)

0.9 (0.4)

0.36 (0.18)*

PPV/Crs (%)

0.27 (0.21)

0.13 (0.09)*

0.23 (0.13)

0.16 (0.11)

0.48 (0.29)

0.27 (0.20)

  1. Values are mean (SD).
  2. HR heart rate, SAP systolic arterial pressure, MAP mean arterial pressure, CI cardiac index, SVI stroke volume index, SVRI systemic vascular resistance index, Pplat plateau pressure, Pmean mean airway pressure, Crs respiratory system compliance, PPV pulse pressure variation, SVV stroke volume variation.
  3. *Significantly different from its prior baseline value at 5% level.
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