Table 2 Multivariable Cox analyses of clinical features on OS and DFS in patients with T2DM.
Evaluated factors | Multivariable (OS) | Multivariable (DFS) | ||
|---|---|---|---|---|
HR (95.0% CI) | P | HR(95.0% CI) | P | |
Age at diagnosis | 0.003 | 0.013 | ||
≤ 55 years | 1 | 1 | ||
> 55 years | 1.302 (1.094–1.549) | 1.247 (1.048–1.484) | ||
BMI | 0.000 | 0.000 | ||
< 25 | 1 | 1 | ||
25–30 | 1.280 (1.070–1.532) | 1.300 (1.087–1.556) | ||
≥ 30 | 1.696 (1.300–2.213) | 1.753 (1.344–2.286) | ||
Tumour size | 0.000 | 0.000 | ||
≤ 2 cm | 1 | 1 | ||
> 2 cm, ≤ 5 cm | 1.261 (1.053–1.511) | 1.259 (1.051–1.507) | ||
> 5 cm | 2.281 (1.602–3.247) | 2.234 (1.569–3.182) | ||
Uncertain | 1.248 (0.897–1.736) | 1.241 (0.892–1.726) | ||
Lymph node metastasis | 0.000 | 0.000 | ||
0 | 1 | 1 | ||
1–3 | 2.684 (2.158–3.338) | 2.716 (2.184–3.376) | ||
4–9 | 3.960 (3.072–5.105) | 4.096 (3.178–5.280) | ||
≥ 10 | 9.264 (7.339–11.695) | 9.837 (7.782–12.433) | ||
ER status | 0.012 | 0.016 | ||
Negative | 1 | 1 | ||
Positive | 0.738 (0.563–0.967) | 0.738 (0.563–0.967) | ||
Unknown | – | – | ||
PR status | 0.025 | 0.017 | ||
Negative | 1 | 1 | ||
Positive | 0.745 (0.580–0.958) | 0.730 (0.569–0.938) | ||
Unknown | – | – | ||
Ki-67 | 0.009 | 0.007 | ||
Low | 1 | 1 | ||
High | 1.255 (1.017–1.547) | 1.285 (1.042–1.584) | ||
Uncertain | – | – | ||
Groups | 0.000 | 0.000 | ||
Non-diabetes | 1 | 1 | ||
Metformin | 0.386 (0.248–0.601) | 0.384 (0.247–0.598) | ||
Insulin | 1.307 (0.848–2.014) | 1.205 (0.781–1.858) | ||
