Table 3 DAS28-ESR components in the ACarPA+ patients relative to the ACarPA EA patients at baselinea.

From: Increased disease activity in early arthritis patients with anti-carbamylated protein antibodies

Component/Adjustment

βb

SE

p value

ACarPA+ EMM

ACarPA EMM

Swollen Joint Count

noc

0.18

0.03

3.02 × 10–8

4.80 (4.20–5.43)

2.99 (2.69–3.28)

basicc

0.18

0.03

1.28 × 10–8

4.80 (4.20–5.43)

2.96 (2.66–3.31)

basic + CCPc

0.12

0.03

0.0004

4.49 (3.92–5.15)

3.28 (2.92–3.69)

basic + RFc

0.14

0.03

0.00005

4.58 (3.96–5.24)

3.17 (2.79–3.53)

basic + CCP & RFc

0.12

0.03

0.0008

4.49 (3.88–5.15)

3.31 (2.92–3.69)

Tender Joint Count

noc

0.16

0.03

1.01 × 10–6

5.76 (4.97–6.60)

3.65 (3.24–4.04)

basicc

0.14

0.03

4.25 × 10–6

5.11 (4.37–5.95)

3.28 (2.86–3.69)

basic + CCPc

0.13

0.03

0.0002

5.02 (4.24–5.86)

3.39 (2.96–3.88)

basic + RFc

0.12

0.03

0.0003

4.97 (4.20–5.81)

3.39 (2.96–3.88)

basic + CCP & RFc

0.12

0.03

0.0006

4.97 (4.20–5.81)

3.42 (2.96–3.92)

Patient Global Assessment

noc

0.09

0.03

0.006

48.21 (45.18–51.25)

43.17 (41.27–45.07)

basicc

0.08

0.03

0.01

47.0 (43.79–50.20)

43.34 (40.22–44.46)

basic + CCPc

0.06

0.03

0.07

46.54 (43.27–49.80)

42.97 (40.68–45.27)

basic + RFc

0.08

0.03

0.02

46.97 (43.67–50.27)

42.37 (40.10–44.64)

basic + CCP & RFc

0.07

0.04

0.049

46.78 (43.47–50.08)

42.81 (40.49–45.13)

Erythrocyte Sedimentation Rate

noc

0.12

0.03

0.0001

27.11 (24.53–29.96)

21.33 (20.09–22.87)

basicc

0.12

0.03

0.00006

24.78 (22.20–27.39)

19.49 (18.54–20.91)

basic + CCPc

0.07

0.03

0.044

23.57 (21.33–26.31)

20.70 (19.30–22.42)

basic + RFc

0.08

0.03

0.015

23.81 (21.33–26.58)

20.29 (18.92–21.98)

basic + CCP & RFc

0.06

0.03

0.067

23.57 (21.12–26.05)

20.91 (19.30–22.42)

  1. aData from 978 EA patients were analyzed in the first row of each component and 99% of them in the remaining rows.
  2. bResults are presented as in the Table 2.
  3. cThe analyses were performed as in the Table 2 except that sqr(SJC), sqr(TJC) and ln(ESR) transformations were used in the general linear regression. EMM and their 95% CI corresponding to these three measures were back-transformed for reporting.