Table 4 Increased disability, pain and physician global assessment in the ACarPA⁺ patients at baseline^a.

Measure/Adjustment	β^b	SE	p value	ACarPA⁺ EMM	ACarPA⁻ EMM
Disability index (HAQ)
no^c	0.09	0.03	0.008	1.18 (1.09–1.27)	1.03 (0.98–1.09)
basic^c	0.08	0.03	0.008	1.13 (1.03–1.22)	0.98 (0.92–1.05)
basic + CCP^c	0.07	0.03	0.04	1.12 (1.02–1.21)	1.00 (0.93–1.07)
basic + RF^c	0.09	0.03	0.008	1.13 (1.04–1.23)	0.98 (0.91–1.05)
basic + CCP & RF^c	0.08	0.04	0.02	1.13 (1.03–1.23)	0.99 (0.92–1.06)
Pain (VAS)
no^c	0.07	0.03	0.021	49.66 (46.43–52.89)	45.18 (43.16–47.20)
basic^c	0.07	0.03	0.041	47.72 (44.31–51.13)	43.79 (41.53–46.04)
basic + CCP^c	0.05	0.03	0.151	47.33 (43.86–50.81)	44.33 (41.90–46.77)
basic + RF^c	0.06	0.03	0.065	47.69 (44.19–51.20)	43.82 (41.41–46.23)
basic + CCP & RF^c	0.06	0.04	0.117	47.54 (44.02–51.05)	44.19 (41.72–46.65)
Physician Global Assessment
no^c	0.18	0.03	4.12 × 10^–8	42.63 (39.92–45.34)	33.58 (31.86–35.30)
basic^c	0.18	0.03	5.47 × 10^–8	42.46 (39.59–45.32)	33.59 (31.66–35.51)
basic + CCP^c	0.14	0.04	9.82 × 10^–5	41.60 (38.70–44.50)	34.79 (32.74–36.85)
basic + RF^c	0.17	0.04	2.13 × 10^–6	42.21 (39.27–45.16)	33.83 (31.79–35.87)
basic + CCP & RF^c	0.15	0.04	3.98 × 10^–5	41.92 (38.99–44.85)	34.59 (32.52–36.67)

^aData from 949, 966 and 903 patients were available for the first-row analysis of the HAQ, VAS and PhGA analyses, respectively. The remaining analyses counted with 99% of these patients.
^bThe results are presented as in the Table 2.
^cThe analyses were performed as in the Table 2.

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