Figure 5 | Scientific Reports

Figure 5

From: Paracetamol (acetaminophen) rescues cognitive decline, neuroinflammation and cytoskeletal alterations in a model of post-operative cognitive decline (POCD) in middle-aged rats

Figure 5

Hippocampal α-tubulin PTMs are altered following exposure to anaesthesia or surgery. (A) Tyr-Tub/Glu-tub ratio is decreased in MA animals exposed to anaesthesia only and in the surgery model groups treated with Bup-0.05 mg/kg or Par-75 mg/kg compared to MA control. (B) Δ2/TOT-Tub ratio is increased in MA animals exposed to anaesthesia only and in the surgery model groups treated with Bup-0,05 mg/kg or Bup-0.1 mg.kg (s.c.) or Par-75 mg/kg or Par150mg/kg (i.p.) compared to MA control. Surgery animals treated with Bup-0.1 mg/kg had significantly higher Δ2/Tot-Tub ratio compared to MA animals exposed to anaesthesia only. Histograms represent data expressed as a percentage of the MA Control group (mean ± SEM), n = 10–12 per group. One-way ANOVA followed by Fisher’s LSD analysis ***p < 0.0001, **p < 0.01, *p < 0.05 vs. MA control; #p < 0.01, ##p < 0.01 vs. MA + Anaesthesia group.

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