Table 2 Analysis of cytokine levels in hippocampal tissue.
Hippocampus cytokines | MA control | MA + anaesthesia | MA + surgery model (Bup-0.05 mg/kg) | MA + surgery model (Bup-0.1 mg/kg) | MA + surgery model (Par-75 mg/kg) | MA + surgery model (Par-150 mg/kg) | F value |
|---|---|---|---|---|---|---|---|
Pro-inflammatory | |||||||
TNF-α | 100 ± 11 n = 5 | 101 ± 9.6 n = 8 | 104 ± 13 n = 5 | 92 ± 6 n = 6 | 108 ± 11 n = 8 | 141 ± 11*# n = 8 | F(5, 34) = 2.643 p = 0.0402 |
IFN-γ | 100 ± 6 n = 8 | 100 ± 6 n = 9 | 103 ± 6 n = 5 | 109 ± 20 n = 5 | 109 ± 5 n = 9 | 112 ± 6 n = 10 | F(5, 41) = 0.4818 P = 0.7877 |
IL-1β | 100 ± 2 n = 8 | 102 ± 1 n = 9 | 102 ± 3 n = 5 | 104 ± 3 n = 6 | 103 ± 2 n = 10 | 105 ± 2 n = 11 | F(5, 44) = 0.5981 p = 0.7015 |
IL-6 | 100 ± 8 n = 8 | 108 ± 9 n = 10 | 108 ± 9 n = 5 | 93 ± 10 n = 5 | 96 ± 7 n = 7 | 98 ± 11 n = 10 | F(5, 40) = 0.3838 p = 0.8569 |
IL-5 | 100 ± 3 n = 8 | 97 ± 2 n = 7 | Below Detection | 100 ± 2 n = 6 | 102 ± 3 n = 9 | 104 ± 2 n = 9 | F(5, 36) = 0.6622 p = 0.6544 |
KC/GRO (CXCL1) | 100 ± 4 n = 8 | 92 ± 3 n = 8 | 97 ± 8 n = 4 | Below Detection | 100 ± 8 n = 7 | 103 ± 2 n = 8 | F(5, 31) = 0.6642 p = 0.6533 |
Anti-inflammatory | |||||||
IL-10 | 100 ± 16 n = 9 | 84 ± 7 n = 10 | 91 ± 18 n = 5 | 97 ± 15 n = 6 | 118 ± 18 n = 9 | 127 ± 16 # n = 11 | F(5, 45) = 1.234 p = 0.3093 |
IL-13 | 100 ± 8 n = 7 | 112 ± 6 n = 10 | 94 ± 16 n = 5 | 126 ± 12 n = 6 | 164 ± 17**## n = 7 | 162 ± 16**## n = 10 | F(5, 39) = 4.828 p = 0.0016 |
IL-4 | 100 ± 12 n = 8 | 92 ± 7 n = 10 | 86 ± 6 n = 5 | 80 ± 4 n = 6 | 106 ± 12 n = 10 | 101 ± 7 n = 11 | F(5, 45) = 0.9694 p = 0.4467 |
