Figure 6 | Scientific Reports

Figure 6

From: Iron supplementation regulates the progression of high fat diet induced obesity and hepatic steatosis via mitochondrial signaling pathways

Figure 6

Iron supplementation alters the transcription of mitochondrial genes associated with the iron prosthetic groups in the liver and skeletal muscle. (a–c) Male C57BL/6J mice of 6 weeks of age were fed with each diet for 15 weeks as specified in Fig. 1. For each group, a mix of all sample cDNAs was used. (a) Venn diagrams showing upregulated expression of 51 mitochondrial genes in the liver and skeletal muscle of HF + SFC compared with HF (greater than or equal to 1.5-fold). Mitochondrial genes were based on the MitoCarta2.0 database. (b) STRING enrichment analysis of 51 upregulated mitochondrial genes in the liver and skeletal muscle of HF + SFC revealed in (a) (FDR < 0.05). Arrows point to the iron prosthetic groups related pathways. UniProt database was used. The analysis was performed by Cytoscape. (c) The STRING networks of 51 upregulated mitochondrial genes in the liver and skeletal muscle of HF + SFC revealed in (a). These networks are annotated with energy generation and ETC using BiNGO (p < 0.001). The iron prosthetic group related genes (red) and other genes (green) are shown. The analysis was performed by Cytoscape.

Back to article page