Table 2 Quantitative targeted assay analysis.

From: A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure

 

Discharge

Survivor

Nonsurvivor

Day1

Day3

Day1

Day3

Amino acids

Alanine

317 ± 26.8

195 ± 20.2*

209 ± 20.1

218 ± 25.0*

516 ± 210

Arginine

91.6 ± 10.0

73.9 ± 10.3

76.9 ± 9.4

55.4 ± 9.2*

55.7 ± 9.8*

Phenylalanine

81.4 ± 6.8

120.8 ± 24.8

103.9 ± 18.6

120.4 ± 14.7

185.7 ± 35.4*,#

Glycine

333.8 ± 22.6

233.2 ± 19.5*

236.6 ± 24.3

202.5 ± 11.9*

301.7 ± 71.3

Proline

194.7 ± 15.2

169.8 ± 18.4

165.7 ± 16.6

181.5 ± 24.6

290.6 ± 45.8#

Serine

111.0 ± 7.4

85.0 ± 7.4

94.6 ± 8.5

59.3 ± 3.7*

77.1 ± 8.5*

Threonine

155.4 ± 12.6

104.9 ± 11.9*

125.3 ± 17.5

92.3 ± 9.2*

152.3 ± 35.1

AA Derivatives

Asymmetric dimethylarginine

0.61 ± 0.03

0.61 ± 0.06

0.55 ± 0.04

0.71 ± 0.1

0.84 ± 0.08#

Creatinine

161.4 ± 48.7

221.4 ± 75.2

211.7 ± 69.9

293.9 ± 47.5

339.0 ± 47.2*,#

Sarcosine

7.7 ± 0.7

5.1 ± 0.5*

5.3 ± 0.4

5.3 ± 0.6*

6.2 ± 0.7

t4-OH-Pro

14.5 ± 1.8

12.9 ± 2.9

8.4 ± 1.1

15.1 ± 3.0

20.9 ± 4.0#

NAD+

Tryptophan

58.2 ± 5.0

42.6 ± 4.2

47.7 ± 5.7

31.0 ± 3.4*

39.0 ± 5.2

Kynurenine

3.5 ± 0.4

4.7 ± 0.8

4.0 ± 0.6

11.7 ± 4.1*

14.0 ± 3.8*,#

Carnitine esters

Acetylcarnitine

7.0 ± 0.7

9.9 ± 1.5

9.1 ± 1.6

23.6 ± 6.5*

19.6 ± 4.4*

C3-DC (C4-OH)

0.14 ± 0.01

0.19 ± 0.03

0.16 ± 0.02

0.33 ± 0.1*

0.30 ± 0.05*,#

C6 (C4:1-DC)

0.09 ± 0.00

0.12 ± 0.02

0.12 ± 0.02

0.23 ± 0.1*

0.25 ± 0.05*,#

Octanoylcarnitine

0.18 ± 0.01

0.19 ± 0.02

0.21 ± 0.03

0.32 ± 0.1

0.35 ± 0.06*

Acyl-GPCs

lysoPC a C16:0

74.2 ± 7.5

34.4 ± 4.0*

48.0 ± 6.8

16.4 ± 2.4*,#

15.5 ± 3.4*,#

lysoPC a C16:1

2.62 ± 0.30

1.07 ± 0.10*

1.53 ± 0.21*

0.58 ± 0.1*,#

0.61 ± 0.12*,#

lysoPC a C17:0

1.37 ± 0.15

0.63 ± 0.06*

0.87 ± 0.12

0.42 ± 0.0*

0.41 ± 0.08*,#

lysoPC a C18:0

20.2 ± 2.4

9.8 ± 1.4*

13.4 ± 2.1

4.9 ± 0.6*,#

5.3 ± 1.5*,#

lysoPC a C18:1

21.0 ± 4.3

8.8 ± 0.9*

13.3 ± 2.0

4.3 ± 0.5*,#

5.1 ± 1.2*,#

lysoPC a C18:2

29.9 ± 4.3

10.8 ± 1.6*

17.5 ± 3.3

4.8 ± 0.5*,#

5.6 ± 1.7*,#

lysoPC a C20:3

2.49 ± 0.42

1.23 ± 0.11*

1.48 ± 0.19

0.92 ± 0.1*

0.98 ± 0.18*

lysoPC a C20:4

8.7 ± 0.9

4.2 ± 0.5*

5.5 ± 0.9

2.1 ± 0.2*,#

2.1 ± 0.5*,#

Phosphatidyl-cholines

PC aa C32:0

16.7 ± 2.4

15.9 ± 1.9

15.8 ± 1.6

32.5 ± 8.6

50.5 ± 25.6#

PC ae C30:0

0.40 ± 0.03

0.44 ± 0.05

0.40 ± 0.03

0.69 ± 0.1

0.81 ± 0.14*,#

PC ae C40:1

0.98 ± 0.15

0.55 ± 0.05*

0.72 ± 0.11

0.46 ± 0.1*

0.57 ± 0.21

Bile acids

Taurolithocholic acid sulfate

0.09 ± 0.01

0.21 ± 0.04

0.23 ± 0.09

0.71 ± 0.4

0.90 ± 0.34*

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