Figure 2

Overall process for image and statistical analysis. Automated MRI-volumetry analyses using NeuroQuant software package (CorTechs Labs, La Jolla, CA, USA, version 2.3, https://www.cortechslabs.com/products/neuroquant/) were performed via the standard processing pipeline. The ROIs of [18F] THK-5351 PET images were segmented and expressed as Braak I/II, Braak III/IV and Braak V/VI. The performances of individual and combined models were calculated. ROI = region of interest, ROC = receiver operating characteristics.