Table 3 Comparison of combined and individual performance using volumes of selected brain regions, SUVRs of Braak ROIs and volume of the hippocampus in discriminating AD from HC and MCI.
AUROC | P* | Sensitivity (%) | Specificity (%) | Accuracy (%) | |
|---|---|---|---|---|---|
AD vs. HC | |||||
Combined model (volumes of selected brain regions + SUVRs of Braak ROIs) | 0.98 (0.95, 1.00) | 100 | 90.6 | 94.8 | |
Volumes of selected brain regions (cingulate isthmus, inferior parietal lobe, hippocampus) | 0.94 (0.88, 1.00) | 0.094 | 88.5 | 90.6 | 89.7 |
SUVRs of Braak ROIs (Braak I/II, III/IV, V/VI) | 0.88 (0.79, 0.98) | 0.033 | 84.6 | 90.6 | 87.9 |
Volume of the hippocampus | 0.78 (0.65, 0.91) | 0.003 | 53.8 | 96.8 | 77.6 |
AD vs. MCI | |||||
Combined model (volumes of selected brain regions + SUVRs of Braak ROIs) | 0.85 (0.75, 0.94) | 84.6 | 74.5 | 77.8 | |
Volumes of selected brain regions (cingulate isthmus, inferior parietal lobe, hippocampus) | 0.78 (0.68, 0.89) | 0.065 | 75.4 | 80.0 | 75.3 |
SUVRs of Braak ROIs (Braak I/II, III/IV, V/VI) | 0.79 (0.62, 0.92) | 0.178 | 76.9 | 80.0 | 79.0 |
Volume of the hippocampus | 0.48 (0.34, 0.63) | < 0.001 | 38.4 | 69.1 | 59.2 |
