Figure 3

Principal component analysis and linear discriminant analysis derived from miR expression data in plasma. The scatterplots show the representation of each study participant in the first two principal components. The scatterplots (A) and (B) are the same but color-coded according to healthy controls (HC) versus patients with ME/CFS and according to healthy controls, mild/moderate (mm) and severely affected (sa) ME/CFS patients, respectively. The barplots (C) represent the frequency of HC and patients with ME/CFS and their corresponding classification probability of being classified as such according to a linear discriminant analysis distinguishing patients from controls specifically. The barplots (D) are similar to ones shown in (C), but for a linear discriminant analysis distinguishing mild/moderate patients from severely affected patients specifically. The statistical analysis was performed in the R software version 4.0.2 (https://www.r-project.org/).